Monday, April 25, 2011

The dark matter of disease

In the early 2000s, geneticist Len Pennacchio was at the Lawrence Berkeley National Laboratory in California studying coronary artery disease (CAD) and was faced with a conundrum: Despite the fact that CAD was a known heritable disorder, he and his colleagues could not identify any gene that significantly contributed to CAD risk. "It's the number one killer in Western society, yet the genetic explanations have largely remained elusive," he said. More>